Kamila Gorczyca

Medical University of Lublin
Poland

Abstract Title: IL-37 and IL-10 in women with gestational diabetes mellitus

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Introduction: Gestational diabetes mellitus (GDM) is usually defined as hyperglycemia that is diagnosed or develops during pregnancy. GDM is associated with an increased risk of complications during pregnancy. A variety of cells secrete IL-10, which is a pleiotropic regulator of immune tolerance during pregnancy. IL-37, on the other hand, exerts anti- inflammatory effects by suppressing innate and adaptive immunity through inhibition of dendritic cell growth.
Aim: Differences in interleukin levels may be a consequence of the meta-inflammation associated with the diagnosis of GDM and may also be a marker of later metabolic consequences for the mother. Material and methods: We studied 80 patients, including 30 with GDM, who gave birth at the Department of Obstetrics and Perinatology in Lublin, and correlated IL-1F10 and IL-37 levels with gestational weight gain, physical activity, addictions, family and environmental history, body composition, and hydration levels.
Conclusion: Levels of IL-37 were low in postpartum women with GDM in the first days after delivery compared with the control group. There were no statistically significant changes in IL-1F10 levels in postpartum women with GDM. A study conducted in maternity wards in the early postnatal period, before discharge home, a key time for maternal programming, may help to establish recommendations for the postnatal period and subsequent years of life that counteract the development of lifestyle diseases.